In "Road to the Multiverse", two of the show's main characters, baby genius Stewie and anthropomorphic dog Brian, both voiced by series creator Seth MacFarlane, use an "out-of-this-world" remote control to travel through a series of various parallel universes. They eventually end up in a world where dogs rule and humans obey.

A Bertram from an alternate dimension arrives in the main Family Guy timeline, out on a mission to destroy any timeline where he doesn't exist. He builds a multiverse-traveling remote control and goes into another universe as part of his plan to lure Stewie into his trap.