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Dec 10, 2013 · TYPE OF NEWS. Research News (4518) Conference Coverage (1414) Community News (281) Interviews (33) Book Reviews (7) DISEASE. Alzheimer's Disease (3360) Amyotrophic Lateral Sclerosis (541) Parkinson's Disease (477) Frontotemporal Dementia (435) Triplet Repeat Diseases (153) Dementia with Lewy …
‘Proteogenomics’ Ties Genes That Control 38 Proteins to Alzheimer’s
Dec 11, 2024 · Only four of these proteins were cis. Some of the proteins, such as NfL and 14-3-3, are markers for AD or other neurodegenerative diseases while others, including calcineurin, associate with Alzheimer’s pathology (Panda et al., 2024; Dec 2024 news; May 2024 news; Hopp et al., 2018). APOE transports a variety of lipids between cells and ...
Polygenic Scores Point to Microglia, Astrocytes in Alzheimer's ...
Dec 15, 2023 · Curiously, only the astrocytic PRS was tied to poor scores on the preclinical Alzheimer’s cognitive composite (PACC), a test battery that picks up early inklings of cognitive impairment. This held regardless of a person's Aβ or tau-PET measures, suggesting astrocytes might directly influence early changes in cognition.
In Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble
Dec 7, 2024 · In 5xFAD mice, a similar analysis revealed substantial overlap in plaque-associated genes between mouse and human samples. Swarup said the findings bolster previous studies on plaque-induced genes, aka “PiGs” (Jul 2020 news; Feb 2023 news). The agreement across species suggests a common, amyloid-related signature at the heart of different ...
CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before …
Sep 27, 2024 · Three of the proteins—SMOC1, GFAP, and NPTX2—are included in Alamar’s CNS Nulisa platform, a new technique that use nucleic acid tags to amplify antibody signals and detect vanishingly minute amounts of protein (Aug 2024 conference news). Even with just these three proteins, Nulisa measurements teased out mutation carriers, and their ...
Some Alzheimer’s Blood Tests Are Racing Toward IVD Certification
Nov 21, 2024 · Yes, blood tests for Alzheimer’s disease are ready for prime time. So pronounced Suzanne Schindler, Washington University, St. Louis, in a keynote presentation at CTAD 2024 last month in Madrid. In answering a question that has been raised often in the last few years, Schindler said that the field has reached a tipping point, and that highly ...
ALZFORUM | NETWORKING FOR A CURE
Dec 23, 2024 · In Alzheimer’s Due to Down’s, Spatial Omics Spots Signs of Trouble. Add To My AlzForum; 1 comment; 07 Dec 2024. In plaque- and tangle-laden layers of the Down’s syndrome neocortex, neuroinflammation raged, and glia sent death signals to neurons. Do CSF and Plasma NfL Diverge After Alzheimer’s Disease Onset? Add To My AlzForum; 06 Dec 2024
‘MGWAS’ Ties Brain Metabolites to Alzheimer’s, Parkinson’s, More
Dec 12, 2024 · Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients. Neurobiol Aging. 2004 Nov-Dec;25(10):1299-303. PubMed. Zhang F, Rakhimbekova A, Lashley T, Madl T. Brain regions show different metabolic and protein arginine methylation phenotypes in frontotemporal dementias and Alzheimer's disease. Prog Neurobiol. 2023 Feb;221: ...
New Alzheimer’s Diagnostic Criteria Remain ‘Research Only’
Nov 28, 2023 · The latest effort to rewrite the diagnostic criteria for Alzheimer’s disease has stirred more than a little controversy. While the proposed revisions have garnered praise from researchers for more accurately reflecting the underlying biology of the disease, they also have sparked criticism for advancing toward clinical use what were ...
Clinical Trials on Alzheimer's Disease (CTAD) 2023 - 16th
Dec 1, 2023 · The 16th iteration of the Clinical Trials in Alzheimer’s Disease conference, held October 24-27 in Boston, drew some 2,300 participants, of whom 1,500 crowded into a downtown hotel for the in-person experience while 800 followed proceedings remotely.