About 28,000 results
Open links in new tab
  1. The New England Journal of Medicine
    https://www.nejm.org › doi › full

    SLCO1B1 Variants and Statin-Induced Myopathy — A …

    Aug 21, 2008 · We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to achieve the benefits of...

    Tags:
    Myopathy
    SLCO1B1
  2. MedlinePlus
    https://medlineplus.gov › genetics › gene

    SLCO1B1 gene - MedlinePlus

    The SLCO1B1 gene provides instructions for a protein that transports compounds from the blood into the liver for clearance. Mutations in this gene can cause Rotor syndrome, a condition that leads to jaundice, or affect the ability to process …

    Tags:
    Organic anion
    Protein
  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › gene

    SLCO1B1 solute carrier organic anion transporter family member …

    Tags:
    Organic anion
    Homo sapiens
  4. Studies of SLCO1B1
    ascpt.onlinelibrary.wiley.com
    PharmVar GeneFocus: SLCO1B1 - Ramsey - 2023 - Clinical Pharmacology ...
    The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variation within the SLCO1B1 gene locus impacts drug transport, whi...
    Author: Laura B. Rams…
    Published: 07 July 2022
    Cited By: 9
    PubMed
    Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation
    Purpose: OATP1B1 (SLCO1B1) is the most abundant and pharmacologically relevant uptake transporter in the liver and a key mediator of xenobiotic clearance. However, the regulatory mechanisms that determine OATP1B1 activity remain uncertain, and as a result, unexpected drug-drug interactions involving...
    Author: Elizabeth R Ha…
    Published: 2021/08/01
    Keywords: OATP1B1 (…
    PubMed
    PharmVar GeneFocus: SLCO1B1 - PubMed
    The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variation within the SLCO1B1 gene locus impacts drug transport, whi...
    Author: Laura B Ramsey
    Published: 2023/4
    Keywords: National In…
    PubMed
    SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
    SLCO1B1 (solute carrier organic anion transporter family member 1B1) is an important transmembrane hepatic uptake transporter. Genetic variants in the SLCO1B1 gene have been associated with altered protein folding, resulting in protein degradation and decreased transporter activity. Next-generation ...
    Author: Lingxin Zhang
    Published: 2021/5
    Keywords: National In…
  5. Wikipedia
    https://en.wikipedia.org › wiki

    Solute carrier organic anion transporter family member 1B1

  6. AHA/ASA Journals
    https://www.ahajournals.org › doi

    SLCO1B1 and Statin Therapy | Circulation: Genomic and Precision …

    Tags:
    Slco1b1 Testing
    Sony Tuteja, Daniel J. Rader
    Publish Year:2018
  7. GeneCards
    https://www.genecards.org › cgi-bin › car…

    SLCO1B1 Gene - GeneCards | SO1B1 Protein | SO1B1 …

    Oct 2, 2024 · SLCO1B1 is a liver-specific transporter that mediates the uptake of organic anions and drugs. Learn about its function, pathways, disorders, products, variants, antibodies and more from GeneCards database.

    Tags:
    Organic anion
    Slco1b1 Transporter Protein
    Slco1b1 Testing
    Slco1b1 Antibody
  8. People also ask
    What diseases are associated with SLCO1B1?
    SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include Hyperbilirubinemia, Rotor Type and Gilbert Syndrome. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Lovastatin Pathway, Pharmacokinetics.

    SLCO1B1 Gene - GeneCards | SO1B1 Protein | SO1B1 Antibody

    genecards.org
    Which gene encoding SLCO1B1 is associated with impaired transporter function?
    Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] SLCO1B1 (Solute Carrier Organic Anion Transporter Family Member 1B1) is a Protein Coding gene. Diseases associated with SLCO1B1 include Hyperbilirubinemia, Rotor Type and Gilbert Syndrome.

    SLCO1B1 Gene - GeneCards | SO1B1 Protein | SO1B1 Antibody

    genecards.org
    Where is SLCO1B1 located?
    Located on the short arm of chromosome 12 (12p12.1), the SLCO1B1 gene is a relatively large gene spanning 109 kilobases (kb) with 15 exons. As illustrated in Figure 1, the gene locus harbors four closely related genes, SLCO1B1, SLCO1B3, SLCO1B7, and SLCO1A2, encompassing a total of 609 kb.

    PharmVar GeneFocus: SLCO1B1 - Ramsey - 2023 - Clinical Pharmacology

    ascpt.onlinelibrary.wiley.com
    Are SLCO1B1 exons resequenced?
    After the genomewide analysis, we resequenced exons within SLCO1B1 in 83 case patients and 89 controls who had adequate DNA available and included an additional 38 genotyped and 141 imputed 20 variants (using HapMap CEU 21 as a reference population) with a nonzero minor-allele frequency in the case–control analysis.

    SLCO1B1 Variants and Statin-Induced Myopathy — A Genomewide Study

    nejm.org
    When did patients receive SLCO1B1 results?
    Patients in the usual care arm received their SLCO1B1 results at the end of the 8-month study period. Test results and statin dosing recommendations were returned to primary care providers within the electronic health record with minimal disruption to the clinical workflow.

    SLCO1B1 and Statin Therapy | Circulation: Genomic and Precision Medic…

    ahajournals.org
    Should SLCO1B1 testing be standardized?
    Clearly, recommendations are also needed for SLCO1B1 testing to facilitate standardized testing and reporting for this important pharmacogene. Individuals presenting with a single heterozygous variant allows for unequivocal haplotype calls. Two such examples are shown in Figure 3a.

    PharmVar GeneFocus: SLCO1B1 - Ramsey - 2023 - Clinical Pharmacology

    ascpt.onlinelibrary.wiley.com
    Feedback
  9. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    PharmGKB very important pharmacogene: SLCO1B1 - PMC

    Tags:
    Organic anion
    Slco1b1 Transporter Protein
  10. Wiley Online Library
    https://ascpt.onlinelibrary.wiley.com › doi › full

    PharmVar GeneFocus: SLCO1B1 - Ramsey - 2023

    Jul 7, 2022 · SLCO1B1 encodes for one of the major hepatic influx transport proteins organic anion transporting polypeptide 1B1 (OATP1B1), also referred to as SLCO1B1, and previously as OATP-C, OATP2, and liver-specific …

    Tags:
    Organic anion
    Slco1b1 Pharmvar
    Slco1b1 Phenotype
    Cited By:11
  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › gtr › genes

    SLCO1B1 solute carrier organic anion transporter family member 1B1

    Tags:
    Organic anion
    National Institutes of Health
  12. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Regulation of OATP1B1 Function by Tyrosine Kinase-mediated ...

    Tags:
    Publish Year:2021
  14. Some results have been removed