Open links in new tab
  1. Healthline
    https://www.healthline.com/nutrition/hmb

    Hydroxymethylbutyrate (HMB): Benefits, Downsides, and More

    • HMB is a substance your body produces naturally when it breaks down the amino acid leucine. It may offer benefits as a supplement, possibly helping reduce muscle loss increasing muscle growth fo… See more

    What is HMB?

    HMB is a substance that your body produces naturally.
    It has a few different names, depending on the version of the molecule. It is also known as beta-hy… See more

    Healthline
    Benefits of HMB

    Studies have found that taking HMB may be associated with numerous benefits, … See more

    Healthline
    Taking it with other supplements

    Research has looked into how combining HMB with other supplements may affect exercise performance and muscle building.
    It may provide benefits if you take it with creatine, vit… See more

    Healthline
    Safety, dosage, and recommendations

    HMB appears to be generally safe and well tolerated, with little to no known side effects (37, 38).
    In rare cases, people may experience stomach pa… See more

    Healthline
    Feedback
    Table of Contents
    What is HMB?
    Benefits of HMB
    Taking it with other supplements
    Safety, dosage, and recommendations
     
  1. Studies of HMB New Nutrition
    PubMed
    Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial
    Objectives: Supplementation of high protein oral nutrition shakes supplemented with β-hydroxy-β-methylbutyrate (HP-HMB) has been shown to improve muscle mass, muscle strength, and physical performance in older adults, but the roles of HP-HMB supplementation on the intramuscular adiposity remained un...
    Author: L-N Peng
    Published: 2021
    Keywords: Supplemen…
    PubMed
    Impact of a specialized oral nutritional supplement on quality of life in older adults following hospitalization: Post-hoc analysis of the NOURISH trial
    Background & aims: Both during and after hospitalization, nutritional care with daily intake of oral nutritional supplements (ONS) improves health outcomes and decreases risk of mortality in malnourished older adults. In a post-hoc analysis of data from hospitalized older adults with malnutrition ri...
    Author: Geraldine E B…
    Published: 2023 Sep
    Keywords: Both durin…
    PubMed
    Effects of β-hydroxy β-methylbutyrate (HMB) supplementation on muscle mass, function, and other outcomes in patients with cancer: a systematic review
    Low muscle mass is prevalent among patients with cancer and a predictor of adverse clinical outcomes. To counteract muscle loss, β-hydroxy β-methylbutyrate (HMB) supplementation has been proposed as a potential therapy for older adults and various diseases states. This systematic review aimed to inv...
    Author: Carla M Prado
    Published: 2022/6
    Keywords: Cancer; H…
    ScienceDirect
    Original Research Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial
    Objectives Supplementation of high protein oral nutrition shakes supplemented with β-hydroxy-β-methylbutyrate (HP-HMB) has been shown to improve muscle mass, muscle strength, and physical performance in older adults, but the roles of HP-HMB supplementation on the intramuscular adiposity remained un...
    Published: 2021/06/01
    Cited By: 0
    Keywords: Frailty; sarc…
  2. Clinical Nutrition
    https://www.clinicalnutritionjournal.com/article/S...

    Impact of β−hydroxy-β−methylbutyrate (HMB ... - Clinical Nutrition

  3. Clinical Nutrition ESPEN
    https://clinicalnutritionespen.com/article/S2405-4577(22)01271-2/fulltext

    Long-term effects of oral nutritional supplement with hmb on …

  4. nutrition.org
    https://jn.nutrition.org/article/S0022-3166(22)14359-2/fulltext

    β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans …

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34179932

    Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate …

  6. Clinical Nutrition ESPEN
    https://clinicalnutritionespen.com/article/S2405-4577(20)31017-2/fulltext

    Effects of oral nutritional supplement with HMB on clinical …

  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/37757502

    Impact of a specialized oral nutritional supplement on quality of …

  8. Clinical Nutrition ESPEN
    https://clinicalnutritionespen.com/article/S2405-4577(22)00633-7/fulltext

    Effect Of An Oral Nutritional Supplement Containing Β-HYDROXY …

  9. Springer
    https://link.springer.com/article/10.1007/s12603-021-1621-7

    Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate …

  10. Men's Health
    https://www.menshealth.com/nutrition/a6…

    Experts Explain if HMB Supplements Can Help You …

    Apr 30, 2024 · HMB, or hydroxymethylbutyrate, is being touted online as a muscle building supplement. Dietitians explain what HMB is, its health benefits, and risks.