With the latest injury to WR Brandon Aiyuk, the 49ers will have to find ways to win using their depth players.

The team will likely rely on Dorian Thompson-Robinson, veteran Winston or newly-acquired Bailey Zappe at quarterback with the ...

Injuries always have a significant effect on the NFL season, but some teams are bearing the brunt of absences more than ...

Here is a player-by-player look at the 49ers’ injury-ravaged receiving corps entering Sunday’s game against the Dallas ...

After exiting Sunday's game with a pneumonia-like illness, Deebo Samuel has been released from the hospital, per NFL ...

Like Dallas, the Niners have struggled through some of the season’s early portion due to various key injuries.

When Ricky Pearsall finally made his debut for the San Francisco 49ers in Week 7, it felt like a special moment not just for fans of the red and gold but of the NFL, period. A first-round pick, fresh ...

The NFL Trade Deadline is now officially just two weeks away and, as we also approach the midway point of the regular season, how things could play out are star ...

Injuries to some of their dynamic playmakers left the 49ers with few proven options for Brock Purdy to throw during Sunday’s ...

San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

The 49ers’ lone screen on Sunday went to rookie Jacob Cowing, who gained nine yards. It’s something he did well in college.

Coach Kyle Shanahan said tests Monday confirmed the initial diagnosis Aiyuk tore his ACL and would need major reconstructive ...