Shares of McDonald's and 3M are trading lower Wednesday afternoon, propelling the Dow Jones Industrial Average selloff. Shares of McDonald's and 3M have contributed to the index's intraday decline, as the Dow was most recently trading 505 points lower (-1.

The Dow Jones Industrial Average and other major indexes opened lower on Wednesday as the yield on the benchmark 10-year U.S. Treasury note continued its upward climb, reaching 4.23%—a level not seen since July.

The Centers for Disease Control and Prevention said on Tuesday that the “severe” E. coli outbreak had infected 49 people, leaving 10 in hospital and one elderly person dead. Everyone interviewed by authorities investigating the outbreak reported having eaten McDonald’s before falling ill.