Israel struck several targets across Syria and Iraq as part of its wide-reaching response to Iran on Saturday. In Syria, Israel struck military targets across the center and south of the country, Syrian media confirmed.

Some 430,000 people have crossed from Lebanon to Syria since Israel's campaign started, she said. "The attacks on the border crossings are a major concern," she said. "They are blocking the path to safety for people fleeing conflict." Sign up here.

Israel hit back at Iran early on Saturday, saying its military was conducting strikes against military targets, as Iranian media reported multiple explosions. The Middle East has been on edge in anticipation of Israeli retaliation for a ballistic-missile barrage carried out by Iran on Oct.

The Israeli military confirmed on Friday that it had struck a border crossing between Syria and Lebanon that it said was being used by Hezbollah to transfer weapons.

Lebanon's Transport minister said on Friday that Israeli bombing made a second border crossing between the country and Syria inoperable -- leaving only one main official passage between the two