Oxysterol-binding protein - Wikipedia
WEBThe oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of lipid transfer proteins (LTPs). Concretely, they constitute a family of sterol and phosphoinositide binding and transfer proteins in eukaryotes [ 2 ] that are conserved from yeast to humans.
Oxysterol-Binding Protein: new insights into lipid transport …
WEBSep 1, 2023 · Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts …
Oxysterol-binding proteins - PubMed
WEBEvidence for rapid, energy-independent transport between organelles has implicated transport proteins, in particular the eukaryotic oxysterol binding protein (OSBP) family. Since the founding member of this family was identified more than 25 years ago, accumulated evidence implicates the 12-member family of OSBP and OSBP-related proteins (ORPs ...
Functions of Oxysterol-Binding Proteins at Membrane Contact …
WEBJun 23, 2021 · Oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of LTPs known to harbor lipid ligands, such as cholesterol and phospholipids. ORPs act as a sensor or transporter of those lipid ligands at membrane contact sites (MCSs) where two different cellular membranes are closely apposed.
Getting to Grips with the Oxysterol-Binding Protein Family – a …
WEBAug 28, 2024 · Oxysterol-Binding Protein is not a major Transcriptional Regulator of Sterol Homeostasis. Early observations had shown that 27-carbon oxygenated derivatives of cholesterol, or oxysterols, act as potent suppressors of cholesterol biosynthesis (Kandutsch et al., 1978).
The Diverse Functions of Oxysterol-Binding Proteins
WEBNov 10, 2010 · Oxysterol-binding protein (OSBP)-related proteins (ORPs) are lipid-binding proteins that are conserved from yeast to humans. They are implicated in many cellular processes including signaling, vesicular trafficking, …
Oxysterol-binding proteins: sterol and phosphoinositide sensors ...
WEBOxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute a family of sterol and phosphoinositide binding proteins conserved in eukaryotes. The mechanisms of ORP function have remained incompletely understood.
Functions of Oxysterol-Binding Proteins at Membrane Contact
WEBJun 24, 2021 · Oxysterol-binding protein (OSBP)-related proteins (ORPs) are a family of LTPs known to harbor lipid ligands, such as cholesterol and phospholipids. ORPs act as a sensor or transporter of those lipid ligands at membrane contact sites (MCSs) where two different cellular membranes are closely apposed.
Oxysterol-Binding Protein - an overview | ScienceDirect Topics
WEBOxysterol-Binding Protein (OSBP) is a 807 amino acid cytosolic protein that binds cholesterol and 25-hydroxycholesterol and transports sterols from lysosomes to the nucleus, thus downregulating the genes for LDL receptor, HMG-CoA …
Structural mechanism for sterol sensing and transport by OSBP …
WEBSep 1, 2005 · The oxysterol-binding-protein (OSBP)-related proteins (ORPs) are conserved from yeast to humans1,2, and are implicated in the regulation of sterol homeostasis3,4 and in signal transduction...