Kupffer cell - Wikipedia
WEBKupffer cells are incredibly plastic cells that have the capability to polarize specific activation states and can perform different functions in different microenvironments. M1 (classical activation) and M2 (alternative activation) designate the two extremes of macrophage polarization.
Histology, Kupffer Cell - StatPearls - NCBI Bookshelf
WEBDec 30, 2022 · Kupffer cells are specialized macrophages found in the hepatic sinusoid, along with sinusoidal endothelial cells, Ito cells, and pit cells. Kupffer cells are amoeboid-shaped and are attached to the sinusoidal endothelial cells.
Liver macrophages in tissue homeostasis and disease
WEBMar 20, 2017 · Key Points. Liver macrophages comprise Kupffer cells — which are self-maintaining, non-migratory tissue-resident phagocytes that originate from yolk sac-derived precursors during embryogenesis...
Heterogeneity and Function of Kupffer Cells in Liver Injury
WEBJun 27, 2022 · Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of hepatic macrophages even body tissue macrophages. They reside in liver sinusoids towards portal vein. The micro-environment shapes KCs unique immunosuppressive features and functions.
Kupffer Cell Metabolism and Function - PMC - National Center …
WEBKupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.
Hepatic macrophages in liver homeostasis and diseases-diversity ...
WEBOct 12, 2020 · Upon liver injury, resident Kupffer cells (KCs) sense disturbances in homeostasis, interact with hepatic cell populations and release chemokines to recruit circulating leukocytes, including...
Unveiling the antitumor function of ID3 in liver macrophages
WEBMar 1, 2024 · A landmark study reveals how Kupffer cells, resident macrophages of the liver, can promote antitumor immunity. Central to this function is ID3, a Kupffer cell lineage-determining factor. The...
Role of Kupffer Cells in Driving Hepatic Inflammation and Fibrosis …
WEBJun 15, 2020 · The resident liver macrophage, Kupffer cell, is responsible for clearing and responding to these products. We propose that changes in Kupffer cell biology, in the context of HIV infection, creates a mileu that drives hepatic inflammation and fibrosis in response to microbial translocation.
An Eye on Kupffer Cells: Development, Phenotype and the …
WEBAug 30, 2022 · Hepatic macrophages, termed Kupffer cells, are involved in the regulation of multiple liver functionalities. Specific differentiation profiles and functional activities of tissue macrophages have been attributed to the shaping role of the so-called tissue niche microenvironments.
Kupffer cell–like syncytia replenish resident macrophage ... - Science
WEBSep 7, 2023 · Kupffer cells (KCs) are localized in liver sinusoids but extend pseudopods to parenchymal cells to maintain their identity and serve as the body’s central bacterial filter. Liver cirrhosis drastically alters vascular architecture, but how KCs adapt is unclear.