CD44 - Wikipedia
WEBCD44 expression is an indicative marker for effector-memory T-cells. Memory cell proliferation (activation) can also be assayed in vitro with CFSE chemical tagging. In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.
CD44 as a tumor biomarker and therapeutic target - PMC
WEBDec 10, 2020 · In this review, we focus on current data relevant to CD44, and outline CD44 structure, the regulation of CD44, functional properties of CD44 in carcinogenesis and cancer progression as well as the potential CD44-targeting therapy for cancer management.
The biology and role of CD44 in cancer progression: therapeutic ...
WEBMay 10, 2018 · Here, we review current data on the structural and functional properties of CD44, the known roles for CD44 in tumorigencity, the regulation of CD44 expression, and the potential for targeting CD44 for cancer therapy.
Differences in CD44 Surface Expression Levels and Function
WEBJul 14, 2015 · CD44 is a prominent activation marker which distinguishes memory and effector T cells from their naïve counterparts. It also plays a role in early T cell signaling events as it is bound to the lymphocyte-specific protein kinase and thereby enhances T cell receptor signalling.
CD44: From adhesion molecules to signalling regulators
WEBJan 1, 2003 · The CD44 transmembrane glycoprotein family adds new aspects to these roles by participating in signal-transduction processes — not only by establishing specific transmembrane complexes, but...
CD44: A Multifunctional Mediator of Cancer Progression
WEBDec 9, 2021 · CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess several CSC traits, such as self-renewal and epithelial-mesenchymal transition (EMT) capability, as well as a resistance to chemo- and …
CD44 as a tumor biomarker and therapeutic target
WEBDec 10, 2020 · In this review, we focus on current data relevant to CD44, and outline CD44 structure, the regulation of CD44, functional properties of CD44 in carcinogenesis and cancer progression as well as the potential CD44-targeting therapy for cancer management.
CD44: can a cancer-initiating cell profit from an abundantly
WEBMar 10, 2011 · CD44 has been implicated as a cancer-initiating cell (CIC; also known as a cancer stem cell) marker in several malignancies of haematopoietic and epithelial origin.
Single-cell transcriptomics identifies CD44 as a marker and …
WEBJan 29, 2020 · Using single-cell transcriptome analysis and antibody screening, we identify CD44 as a marker of EHT enabling us to isolate robustly the different stages of EHT in the aorta-gonad-mesonephros...
The Importance of CD44 as a Stem Cell Biomarker and …
WEBApr 21, 2016 · CD44 is a compelling marker for cancer stem cells of many solid malignancies. In addition, interaction of HA and CD44 promotes EGFR-mediated pathways, consequently leading to tumor cell growth, tumor cell migration, and chemotherapy resistance in solid cancers.